If there's one game that deserves a legitimate, dedicated shot at the Platinum Trophy, it's Uncharted 3: Drake's Deception .
But maybe it'll help to see the challenges ahead of time. You know, chart 'cough' your approach. Check out the full list over at Joystiq and see if the Platinum is doable in your eyes.
Many of the Bronzes seem perfectly doable; you'll get some Trophies for finding a certain number of treasures, nailing 20 Headshots, defeating 20 enemies while blind-firing in cover, defeat 20 enemies with gunfire while hanging, and defeat 30 enemies with any of the weapons in the game (make sure to keep experimenting!). I like the idea of Master Ninja (Defeat 50 enemies with stealth attacks) and He's Gonna Need a Sturgeon (Hit three enemies with fish in the market). The latter just sounds silly.
Unsurprisingly, the Silver Trophies are a bit more troublesome, as you'll have to take down 75 enemies in a row without dying, find all the treasures, and become the bizarre Rolling Ammo Master: 20 times in a row, pick up ammo while rolling. There's only one Gold Trophy and it's gonna take the majority of your time; you have to beat the game on Crushing difficulty. …good luck with that.
Related Game(s): Uncharted 3