Mass Effect 3 is the end of a trilogy, and that means the main character must also say goodbye.
Although it's certainly possible that BioWare could've continued the franchise with Commander Shepard at the helm (the start of a new trilogy, perhaps), producer Michael Gamble says that won't happen .
First, studio boss Ray Muzyka promised that ME3 won't mark the end of the series:
"We have ambitious plans to continue this franchise going forward. Mass Effect 3 is simultaneously a couple of different things; a thrilling and epic conclusion to the trilogy as we promised our fans we’d provide for Commander Shepard, but it’s also a brand new beginning – it’s an entry point for new fans and it’s also a brand new beginning."
Then, Gamble clarified- "After this, Commander Shepard's story is complete." Therefore, even when BioWare does produce more titles in the Mass Effect world, Shepard won't be involved. Obviously, this begs the question: how will the Commander go out in ME3? Anybody want to hazard a guess?
Related Game(s): Mass Effect 3