We'll see the unveiling of a previously unannounced title at the Spike VGAs on December 11 – followed by that mystery PS3 exclusive reveal on the 12th – and it seems one source has the VGA answer.
According to GamerZines , the unknown game will be a new Resident Evil iteration, possibly the one in the works at one-time SOCOM developer, Slant Six. The "Zombie Teaser" has a Biohazard symbol attached, so that's one piece of evidence and the second is the zombie silhouette they have circled in red in the teaser vid:
"Take a look at the second image, a print from a T-shirt which is part of the official Resident Evil merchandise. Same pose, same zombie. Not only that, but the other zombie that appears in the teaser is also on the shirt design, only facing the other way."
So yeah, if you put two and two together; i.e., the same zombie silhouettes from an official RE t-shirt appearing in a VGA teaser for a zombie-related game. We know Resident Evil 6 is in the works but there's that previously mentioned unconfirmed RE in development at Slant Six, so…hard to say what to expect at this point. But let's say, for the sake of argument, that it's a different type of Resident Evil ; maybe a departure of some kind.
What might it be like…?