Oh, don't be too upset. We all knew that Mass Effect 3 was the end of a trilogy and as such, the end of a story arc.
So it might not make much sense to have protagonist Commander Shepard return in any new iteration of the franchise. There's almost no doubt that BioWare will give us a new ME installment at some point and when they do, it'll be a fresh "starting point." Here's what BioWare Montreal producer Fabrice Condominas had to say about the future :
"There is one thing we are absolutely sure of–there will be no more Shepard, and the trilogy is over. This is really our starting point. Now the Mass Effect universe is vast, and very, very rich. So at this point in time, we don't even know what kind of time frame we're going to be in. All we're doing is more gathering ideas from the teams, gathering feedback to see several things."
Trilogies end, main characters go away. We all had to bid Ezio goodbye after three Assassin's Creed installments and this year, we greet Connor for the first time in ACIII. Condominas says they don't want to make "Shepard 2;" they'd rather create something in a "very, very different context." And you know, we're willing to bet the Mass Effect followers are just fine with that. Aren't they…?