It's one of the most critically acclaimed and best-selling franchises of the generation, so it's no surprise to hear that publisher Electronic Arts would be more than willing to back another installment.
Technically, the Mass Effect series was a trilogy and therefore, this year's ME3 brought that story arc to a close. However, developer BioWare has often said they'd consider returning to the ME universe, even if it required a slightly different setting and cast of characters. The good news is that EA would be right there, ready to publish the new effort, if BioWare chose to do it.
EA Labels president Frank Gibeau obviously thinks quite highly of BioWare writer and director Casey Hudson:
"Does [Mass Effect 3's ending] mean you can never tell another story in the Mass Effect universe? No. If (BioWare’s) Casey decides on a story that he wants to tell, guess what? He’s going to be able to step forward at EA and we’re going to back him with capital for him to be able to go build that experience and tell a new story in the Mass Effect universe if that’s what he wants to do. If he wants to do something different, a new IP, he’ll have our backing as well. He’s a profoundly talented guy. He’s got our confidence. And the audience loves him. So that’s how it really works."
So although BioWare is undoubtedly turning their full attention to the next Dragon Age , there's the distinct possibility that Mass Effect will return…perhaps in the next generation?