If you're looking for another survival/horror game with Shinji Mikami's name on it – the Resident Evil guru is branching out, as you probably already know – you've got one: It's code-named "Zwei."
Mikami's first project with his new Tango Gameworks was revealed in Famitsu and summarized at Andriasang ; as it turns out, Mikami is the game's executive director and is "fully involved" in the development. The last time he was in a similar position was when he worked on Platinum's Vanquish .
The genre is indeed survival/horror and he said he wants to "meet player expectations," and he listened to feedback during meetings with Zenimax (Tango's parent). Right now, it's a long way from being complete; Mikami says about half the basic settings are done, but at least development will be "speeding up" in the near future. Tango is currently hiring and they're especially looking for "talented programmers," so that's a good sign. As for Bethesda's role in the whole process, Mikami says it's "mostly through support as a publisher."
Hopefully, we'll learn more about "Zwei" some time soon.